MedWise Risk Score: A Next-Generation Tool for Medication Safety and Optimized Pharmacotherapy in the U.S
Introduction Medication safety and optimization remain key challenges in modern health care in the United States. Polypharmacy, drug–drug interactions, patient comorbidities, and variable pharmacokinetics/pharmacodynamics raise the risk of adverse drug events (ADEs), hospitalizations, and increased healthcare costs. In response, advanced clinical decision support tools are emerging to help clinicians and pharmacists stratify risk and personalize medication regimens. One such tool is Drug MedWise , which includes the proprietary MedWise Risk Score (MRS) . This article explores its design, evidence base, practical applications, and challenges for adoption in U.S. settings. What is MedWise? An Overview MedWise Technology & Risk Score : MedWise is a decision support system developed by Tabula Rasa HealthCare. It assesses multiple dimensions of a patient’s medication regimen—including pharmacokinetics, pharmacodynamics, drug–drug interactions, and cumulative risk factor...